生命科学 关键词 ：结肠癌；隐窝干细胞；肿瘤干细胞；信号转导 [gap=1083]Key words : colorectal cancer; crypt stem cell; tumour stem cell; signaling transduction
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基因靶标研究显示t CF 4是维持小肠的隐窝干细胞所必需的(6,7)。
Gene targeting studies indicate that TCF4 is required to maintain the crypt stem cells of the small intestine (6, 7).
有研究表明，大肠癌起源于大肠隐窝干细胞，其基因突变和异常增殖导致大肠癌发生。
It is demonstrated that the cancer cells originated from intestinal crypt stem cells, which are responsible for gene mutation, abnormal tissue proliferation and then cancer formation.
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