就神经氨酸酶抑制剂而言，有一些重大的限制因素，主要是生产能力有限，同时，在许多国家，其价格高得难以负担。
For the neuraminidase inhibitors, the main constraints - which are substantial - involve limited production capacity and a price that is prohibitively high for many countries.
限制使用蓝宝石的因素主要是其价格以及这种材料难于加工和成形。
The use of sapphire is restricted by its cost and because the material is difficult to machine and form.
在实际生产中，不考虑价格因素，筒子架的大小受到两方面的限制。
In practice, and not considering purchase price, the creel size is limited by TWO factors.
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