认识药物代谢的酶学基础,了解药酶的常见底物、诱导剂和抑制剂,合理选用同类药品,能避免有害药物代谢性相互作用的发生。
The adverse drug interactions can be avoided by knowing the enzymology basis of drug metabolism, common substrates, inductors, inhibitors involved and using the same kind of drugs rationally.
结论CYP1A是介导肉桂酸代谢转化的主要酶系,肉桂酸与抑制或诱导CYP1A酶的药物合用可能存在相互作用。
CONCLUSION CYP1A is the major enzyme in metabolism of cinnamic acid. The medicine, which have inducible and inhibitory effects on CYP1A, may have interaction with cinnamic acid.
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