大部分甲醇酵母的表达载体中都含有甲醇酵母醇氧化酶基因一1(A0x1),在该基因的启动子(PAXOI)作用下,外源基因得以表达。PAXOI是一个强启动子,在以葡萄糖或甘油为碳源时。
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该表达载体的构建为进一步研究人id4基因的启动子活性及表达调控奠定了基础。
The construction of expression vector of human ID4 promoter provides a platform for further researches on promoter activity and expression regulation of human ID4 gene.
目前研究表明ARF基因在肿瘤发生过程中可有起一定的作用,ARF基因功能的失活可能主要通过该基因启动子高度甲基化。
Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene.
该启动子的成功克隆和其报告基因载体的构建,为研究SOD2的基因表达调控机制提供了重要基础和工具。
The reporter gene vector driven by SOD2 promoter will provide an experimental tool for the further study on the regulatory mechanism of the SOD2 expression.
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