5杂氮2′脱氧胞苷(5aza2′deoxycytidine,5aza2dC)和苯丁酸钠(sodium phenylbutyrate,SPB)是两种分别通过抑制甲基化转移酶和组蛋白脱乙酰化酶活性起到有效抗肿瘤作用的表观遗传修饰剂。
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苯丁酸钠片 Sodium Phenylbutyrate Tablets
抑制剂苯丁酸钠 sodium phenylbutyrate ; SPB
发现苯丁酸钠 sodium phenylbutyrate ; SPB
近来研究发现苯丁酸钠 sodium phenylbutyrate ; SPB
和苯丁酸钠 sodium phenylbutyrate ; SPB
苯丁酸钠片剂 BUPHENYL TABLET
对羟基苯甲酸丁酯钠 butyl 4-hydroxybenzoate sodium salt ; sodium butyl p-hydroxybenzoate ; benzoic acid, p-hydroxy-, butyl ; butyl p-hydroxybenzoate sodium
4-苯基丁酸钠盐 Sodium 4-Phenylbutyrate ; Sodium 4- PH
苯基丁酸钠盐 Sodium 4-Phenylbutyrate
结论苯丁酸钠具有明显的促进人脑胶质瘤细胞分化的作用。
Conclusion SPB has a significant differentiation-inducing effect on human glioma xenograft, and can be used in clinical trials.
结论苯丁酸钠可明显抑制C6细胞增殖，诱导细胞分化，甚至诱发细胞凋亡。
Conclusions SPB can apparently inhibit the proliferation of C6 cells and can induce cell differentiation and even apoptosis of C6 cells.
结论苯丁酸钠和其它诱导分化剂联合应用可能是部分血液肿瘤有效的诱导分化治疗方法。
Conclusion Phenylbutyrate combined with other differentiation agents may be an effective differentiation therapy in a proportion of hematological malignancies.
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