阳性选择决定了成熟T细胞的MHC限制性，阴性选择使机体获得自身免疫耐受。
The MHC restriction of t cell is determined in positive selection. The tolerance of t cells to autoantigen is acquired during negative selection.
对自身免疫耐受产生机制的揭示将为自身免疫病、超敏反应、移植排斥及肿瘤的治疗提供新的策略。
Understanding the mechanisms of self-tolerance will help to find new strategies for treatment of autoimmune disease, hypersensitivity, transplantation rejection and tumor.
小剂量口服自身抗原诱导免疫耐受可有效地抑制EAE和MS，这已被诸多研究所证实，但其机制尚不清楚。
Oral tolerance by feeding autoantigens is an effective method to prevent EAE and to treat MS, which mechanism has not been made very clear.
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