事实上,当嘌呤存在于肽核酸的链上时,肽核酸- DNA二聚体的稳定性会大大增加。
In fact PNA - DNA duplexes show significantly increased stability when the purines are in the PNA strand.
因此,肽核酸- DNA二聚体的稳定性除了依赖g - C配对的含量外,还与肽核酸链上的嘌呤含量有关。
Thus on top of the dependence on g-c content, the stability of pna-dna duplexes also depends on the purine fraction of the PNA strand.
此外,鉴于肽核酸独特的理化和生物学性能,人们正尝试将其用于生物分子工具、反义和反基因制剂、分子探针和生物传感器。
In addition, the unique chemical, physical and biological properties of PNAs have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular probes and biosensors.
应用推荐