目的观察先天性巨结肠肌间神经丛形态学并分析其意义。
Objective To study the morphology of myenteric nerve plexus in the congenital megacolon.
CRF对豚鼠结肠肌间神经丛有很强的兴奋作用，可诱发慢的兴奋性去极化反应，而且CRF所兴奋的神经元均为表达CRF1受体的神经元。
CRF could evoke a slowly activating depolarizing response that associated with enhanced excitability in myenteric neurons in colon. The cells excited by CRF were all expressed with CRF1 receptor.
结果结肠慢传输型便秘的病理检查可见肠壁神经丛有变性、减少。
Results Pathological findings suggested the nerve plexus in the intestinal wall of STC degenerated and decreased.
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