The most interesting results to date came from studies showing that most of the anti-inflammatory actions of MTX are mediated by adenosine, which may account for the profound effects of MTX on cytokines, cytokine inhibitors, and cell differentiation.
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目的研究前炎症细胞因子对人胸膜间皮细胞（HPMC）释放纤溶酶原激活物抑制剂（PAI 1）的诱导效应。
Objective To investigate effects of two proinflammatory cytokines on the production of plasminogen activator inhibitor 1(PAI 1) by human pleural mesothelial cells(HPMC).
应用库普弗细胞特异性抑制剂三氯化钆后，烧伤大鼠血浆内细胞因子含量变化。
The change in the plasma cytokine contents in scalded rats was determined after the application of gadolinium chloride, a specific inhibitor of Kupffer cells.
缺铁，细胞因子活性增加，血液稀释和使用ACE抑制剂已经被纳入其病因之中。
Iron deficiency, increased cytokine activity, hemodilution and use of ACE inhibitors have been implicated in the etiology.
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