盐酸曲马多片，适应症为用于癌症疼痛，骨折或术后疼痛等各种急、慢性疼痛。
结论不同厂家生产的盐酸曲马多片的溶出度明显不一致，进行溶出度检查有助于控制质量。
Conclusion the dissolution rate of tramadol hydrochloride tablets from different manufacturers were remarkably different, dissolution measurement is needed for controlling the quality.
方法分别采用不同黏度与用量的羟丙甲纤维素(HPMC)，不同主药粒径与稀释剂，不同工艺制备盐酸曲马多缓释片。
METHODS Different particle size of tramadol hydrochloride, viscosity grades and the amount of HPMC, additive content and process were used to prepare tramadol hydrochloride sustained release tablets.
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