研究人员通过破坏下丘脑的黑皮质素受体4 (MC4R)或用药物使其关闭来阻断其反应，结果高密度脂蛋白含量同样会增加。
The researchers got the same high HDL levels results when they blocked the hypothalamus' melanocortin 4 receptor (MC4R) either by knocking it out or shutting it down with other chemicals.
某些新型N-酰化螺哌啶衍生物是人黑皮质素受体的配体和尤其是人 黑皮质素-4受体（MC-4R）的选择性配体。
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R).
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