长久以来，心情与行为变化都被视为额颞叶痴呆的早期警讯，它在全部痴呆症中约占10%。

Mood and behavior changes have long been recognized as early-warning signs of frontotemporal dementia, which accounts for about 10 percent of dementias.

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新研究中的痴呆是一种额颞部位的痴呆，在大脑中掌控判断和行为的额叶、颞叶里发现蛋白的毒性蓄积。

The dementia in the new research is a type of frontotemporal dementia, marked by toxic clumps of proteins in the brain's frontal and temporal lobes, which control judgment and behavior.

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新陈代谢的先天缺陷普遍出现在30岁以前的个体发病状况中。额颞叶痴呆普遍出现在35岁以后发生痴呆症的患者中。

Inborn errors of metabolism were more common in individuals with symptoms appearing before age 30. Neurodegenerative causes were more common in dementias occurring after age 35.

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