调控组蛋白乙酰化修饰过程的组蛋白去乙酰化酶(Histone deacetylases, HDACs),在神经发生过程中发挥着重要作用,参与神经干细胞的增殖、命运决定、分化等多个过程。
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抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂，临床 上用于治疗皮肤T细胞淋巴瘤。
Romidepsin is a potent histone deacetylase inhibitor, and is used in the treatment of cutaneous T-cell lymphoma (CTCL).
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
他们发现，大脑中有一个“开关”控制瘦素的作用，它就是一种名为组蛋白去乙酰化酶5（HDAC5）的酶。
They have discovered an enzyme - histone deacetylase 5 (HDAC5) - has a significant influence on the effect of the hormone.
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