我们对动脉粥样硬化遗传学基础了解的深入来自人群的全基因组关联分析(genome-wide association studies,GWAS)和针对极端表型个体的研究。GWAS时的遗传效应通常较小,需要较大样本量才能检出一个明显的遗传信号。
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的是全基因组关联分析 Genome-Wide Association Study
国际糖尿病:重新回到基因的话题上,对于我们理解糖尿病从全基因组关联分析的研究中会获得哪些便利呢?
International diabetes: Switching back to the discussion in genes, what advantage have been gained into the insight to diabetes from the Whole-Genome Association Study?
本文就近年来全基因组关联分析技术研究RA易感基因的进展做一综述。
This review summarizes the progress in using GWAS for screening of RA susceptible genes.
用传统的家系连锁分析无法对精神分裂症这样的复杂疾病进行基因定位,而全基因组关联分析则为最终发现这些基因提供了较好的策略。
After linkage analysis failed to locate susceptible genes of complex diseases like schizophrenia, it is a better way to process whole-genome association studies.
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