依赖于半胱氨酸蛋白酶的激活，美沙酮通过激活线粒体克服了白血病细胞中的阿霉素耐药、多药耐药、和凋亡抑制。
Depending on caspase activation, methadone overcomes doxorubicin resistance, multidrug resistance, and apoptosis resistance in leukemia cells through activation of mitochondria.
目的通过检测儿童急性白血病多药耐药基因及细胞凋亡调控基因表达水平的改变，分析不同类型白血病的主要耐药机制。
Objective To study the drug resistance in different types of acute leukemia in children, the expression of multidrug resistance gene and apoptosis-related genes were analyzed.
目的探讨CYP3A5基因与白血病细胞多药耐药的关系。
Objective To investigate if CYP3A5 gene is involved in the molecular mechanisms for multiple drug resistance in leukemia cells.
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