...键词： 生物药剂学性质;;口服药物;;溶解性;;稳定性;;膜通透性;;首过作用 [gap=754]Keywords: biopharmaceutical characteristics;oral drug;solubility;stability;membrane permeability;first-pass effect(presyste..
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目的综述药物的生物药剂学性质对药物口服吸收的影响。
Objective To review the impacts of biopharmaceutical characteristics on oral drug absorption.
结果药物的溶解性、稳定性、膜通透性和首过作用等生物药剂学性质是影响药物口服后经胃肠道吸收的主要因素。
Results The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
结论本实验确定了岩白菜素的主要理化性质，有利于其生物药剂学的研究以及新剂型的开发。
These results will be of significance for the investigation of biopharmaceutics and the development of new formulations of bergenin.
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