...白酶(matrix metalloproteinases，MMPs)合成增加，基质金属蛋白酶 特异性抑制物（Tissue Inhibitor of Metalloproteinases,TIMPs)合 成减少，造成软骨细胞外基质 (extracellular matrix,ECM)的合成与 降解失..
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...属蛋 白酶(matrix metalloproteinases，MMPs)合成增加，基质金属蛋白酶 特异性抑制物（Tissue Inhibitor of Metalloproteinases,TIMPs)合 成减少，造成软骨细胞外基质 (extracellular matrix,ECM)的合成与 降解失..
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特异性的抑制物氨基胍 AMG ; aminoguanidine
基质金属蛋白酶的组织特异性抑制物是一组多功能基因家族，它们能特异性地抑制基质金属蛋白酶。
The tissue inhibitor of metalloproteinases (TIMPs) are a large family of multi-functional genes, and they specifically inhibit MMPs.
方法制作肾性高血压大鼠脑动脉瘤模型，系统动态观察脑动脉瘤形成过程中MMP - 2、MMP - 9及其特异性抑制物(TIMP - 1)表达的变化。
Methods a rat model of cerebral aneurysm was established. The dynamic changes of MMP-2, MMP-9 and TIMP-1 expression were examined in the process of aneurysm formation.
目的：观察代偿性心脏增大大鼠心肌肥厚过程中各种炎症反应标记物的动态变化及特异性环氧化酶-2抑制剂的影响。
Objective:To investigate the change of inflammation marker in the development of rats with pressure overloaded hypertrophy myocardium and influence of selective cyclooxygenase-2 inhibitor.
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