一旦两者平衡失调， 细胞因子作用于细胞表面相应受体，活化信号转导因子(signal transducer factor, STF)，将刺激信号传至核内而发挥其基因转录的 调节作用，使机体局部乃至全身发生病理反应［1］.
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目的研究血小板源生长因子(PDGF)对肾小球系膜细胞(MC)表型转化的影响，并探讨丝裂素活化蛋白激酶(MAPK)信号转导途径在其作用中的调控机制。
Objective to investigate effects of PDGF on phenotypic change of glomerular mesangial cells (MC), and study intracellular mechanisms through mitogen-activated - protein kinase (MAPK) pathways.
目的 探讨大鼠急性肺损伤（ALI）过程中，信号转导和转录活化因子-3（STAT3）的活化，及其与细胞因子白介素-6（IL-6）的相关性。
Objective To investigate the activation law of signal transducers and activators of transduction-3(STAT3) and whether cytokine IL-6 can activate STAT3 in acute lung injury (ALI) of rats.
信号转导及转录活化因子3（STAT3）是STAT家族成员之一，也是肿瘤组织中的常见通路。
STAT3, as a member of signal transducers and activators of transcription (STATs) family, which has been recognized as one of the common pathways in cancer cells.
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