...基于家蚕基因组数据库和基因芯片数据,对影响黑色素形成途径中的关键基因家蚕酪氨酸羟化酶基因(Bombyx mori Tyrosine hydroxylase, BmTh)进行了生物信息学分析、表达特征分析、组织原位杂交、干涉实验和酶的活性测定。主要研究结果如下：1.
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酪氨酸羟化酶基因 tyrosine hydroxylase ; TH
人酪氨酸羟化酶基因 Human tyrosine hydroxylase
苯丙氨酸羟化酶基因 phenylalanine hydroxylase gene
能与酪氨酸羟化酶基因 tyrosine hydroxylase gene
色氨酸羟化酶基因 tryptophan hydroxylase gene
结论：NURR1基因结合神经干细胞有效改善了帕金森病模型症状，提高移植后酪氨酸羟化酶阳性神经元细胞的数量。
CONCLUSION: NURR1 gene combined with NSC can effectively ameliorate PD models symptoms and elevate the number of tyrosine hydroxylase positive neurons after transplantation.
目的探讨中国汉族人色氨酸羟化酶(TPH)基因A 218c多态性与单相抑郁症及其症状表型的遗传关联性。
Objective to investigate the association among tryptophan hydroxylase (TPH) gene A218C polymorphism, unipolar depression (UPD) and symptom phenotypes in han nationality of Chinese.
目的：研究内蒙古地区经典型苯丙酮尿症（PKU）苯丙氨酸羟化酶（PAH）基因突变的特点和频率，以提高该地区PKU的基因诊断率。
Objective:To study the mutations of the phenylalanine hydroxylase(PAH)gene and enhance the gene diagnosis of classical phenylketonuria(PKU) in Inner Mongolia.
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