目的：合理设计新的HIV-1整合酶抑制剂。
Objective: To rationally design new inhibitors of HIV-1 integrase.
整合酶抑制剂MK - 0518对以前没接受过抗病毒治疗病人，疗效就像目前最好的药物组合一样有效。
The integrase inhibitor MK-0518 worked as effectively as the best treatment available for individuals who have not previously received antiretroviral therapy.
给出了各个代表性体系的应用价值。旨在对HIV - 1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
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