唑尼沙胺为白色至微黄色结晶或结晶性粉末,无臭,味苦。极易溶于丙酮,溶于甲醇、乙醇、乙酸乙酯或乙酸,微溶于水、正己烷、乙醚或氯仿。中文别名1,2-苯异恶唑-3-甲烷磺酰胺;分子式:C8H8N2O3S ;用于癫痫大发作、小发作、局限性发作、癫痫持续状态及精神运动性发作。
该研究由发现唑尼沙胺的住友制药资助。
The study was supported by Dainippon Sumitomo Pharma, which discovered zonisamide.
唑尼沙胺的治疗改善了患者的主要帕金森病症状,包括震颤和其它运动障碍。
Zonisamide treatment improved all main Parkinson disease symptoms in these patients, including tremor and other disabling dyskinesias.
Murata说现在还不完全清楚唑尼沙胺如何帮助改善帕金森病的症状,需要更多的研究来阐明该药物起效的机制。
Murata says it's not fully understood yet as to why zonisamide helps Parkinson disease symptoms and further study is needed to clarify the mechanism behind the drug's benefits.
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