本实 验通过利用SD 大鼠吗啡条件性位置偏爱（conditioned place preference，CPP）-消退-环境激发模型，研究吗啡成瘾记忆重现状态 下，大鼠海马区突触后致密质95（PSD-95）的表达...
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目的：探讨5-HT3型受体特异性拮抗剂奥丹西隆对吗啡诱导的条件性位置偏爱（CPP）效应的影响及其可能机制。
OBJECTIVE:To elucidate the effect of ondansetron(OND), a 5-HT3 receptor antagonist, on the morphine-induced conditioned place preference(CPP) in mice and its possible mechanism.
方法··：毁损依赖大鼠腹侧苍白球，利用条件性位置偏爱实验测定术前、术后依赖大鼠对注射吗啡侧的偏爱程度，评价腹侧苍白球在药物强化效应程度中的作用。
Method: Electrical lesions of ventral pallidum were done in 12 morphine dependent rats and the drug seeking behavior was measured by conditioned place preference paradigm.
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