目的评价非糖皮质激素的免疫抑制方案防止大鼠同种异体胰岛移植排斥反应的效果。
Objective To evaluate the effect of anti-rejection of glucocorticoid-free immunosuppressive regimen on allogenic islet transplantation.
连续口服FTY720可有效延长小鼠同种异体胰岛移植物存活时间并呈一定的剂量相关性。
Conclusion Continuous administration of FTY720 can effectively prolong the survival time of islet allograft in mice, which is dose related.
选择在移植时同时抑制CD4和CD 8依赖的免疫途径的特异性免疫保护胰岛同种异体移植物，从早期和晚期的免疫损害。
Selection of specific immunotherapy to suppress both CD4 - and CD8-dependent immune pathways at the time of transplant protects islet allografts from both early and late immune damage.
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