这些靶基因常常编码一些转录因子，其中许多都是发育上重要同源结构域蛋白（homeodomain proteins）。同源结构域蛋白共同起作用，形成了一个由自我调节（autoregulatory）和反馈（feedforward）的循环组成的调节通路。
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Arx（Aristaless-related homeobox）蛋白是成对同源结构域蛋白家族的一个成员。
The Arx protein(Aristaless-related homeobox) is a member of the paired class of homeoproteins.
并应用生物信息学方法分析该基因的同源性、蛋白结构域及跨膜拓扑结构。
Bioinformatic methods were employed to analyze the homology of the nucleotide and amino acids sequence of beta subunit gene and its possible protein domain and transmembrane topology.
运用基于基因组数据库的特定基因同源新基因的克隆策略得到一个人类新基因WDR70，该基因编码一个包含12个WD 4 0结构域的蛋白。
A human novel gene WDR70 is obtained with the cloning strategy of novel homologous gene, which is a specific gene based on genome database. It encodes a protein of 12 WD40 domain.
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