合理化药物设计利用靶分子和其结合分子的高分辩率结构。

Rational drug design (also known as structure-based drug design) uses the high-resolution (atomic) structure of the target molecule, and of molecules that bind to it.

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综述了喜树碱及其衍生物的小分子、大分子和轭合物前药的研究进展，为新型喜树碱前药的合理药物设计提供一定参考。

The recent progress in low molecular, high molecular and couplet prodrugs of CPTs was reviewed in classified manner, provide a reference for the design of prodrugs of CPTs.

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计算机辅助药物分子设计近年来已成为新药创制的重要手段。 基于结构的合理药物分子设计则是多学科交互融合和渗透的体现。

Computer-aided molecular design (CAMD) is now an uprising subject in medicinal chemistry among which structure-based rational drug design is attracting more and more attention.

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