当囊壁较厚时,药物的释放可分为4个阶段: ①初期的突释(burst effect) :来自微囊外表面药物; ②慢速释放:来自囊内的药物透过囊壁扩散; ③较快速的稳态扩散释放:来自囊内的药物饱和溶液, 维持时间最长...
基于10个网页-相关网页
该蛋白微球新剂型改善了载药微球悬浮液的稳定性，抑制了释药初期的突释现象。
Zein microsphere tablets improved the stability of the zein microsphere enclosed drugs in suspension and suppressed the phenomenon of sudden release at the first stage of delivery.
膜片表面空球和PVA涂层两种保护形式中，空球保护可明显减弱膜片的初期突释，而PVA涂层保护由于其很快脱落，对膜片的突释抑制不明显。
The burst release of wafer protected by blank MS was restrained, however, no obvious restrain effect was observed for wafer protected by PVA for its quickly falling off.
应用推荐