IL1β可引起IL6[17,18]及IL11[19]的释放,促进骨溶解。另外,TNFα、IL1可诱导人成骨细胞(human osteoblasts,HOB)、MG63细胞表达MMP1[21],IL6还可诱导小鼠成骨细胞MMP2、MMP3及MMP13表达[6],直接引起细胞外骨基质降解。
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Objective To observe the effect of leptin on osteoblast.
目的观察瘦素(leptin)对人成骨细胞增殖和功能的影响。
参考来源 - Leptin对人成骨细胞增殖和功能的影响 The Effects of Leptin on Proliferation and Function of Human Osteoblast·2,447,543篇论文数据,部分数据来源于NoteExpress
目的:研究周期性牵张力对人成骨细胞基因表达谱的影响。
Objective: To study the effects of cyclic tensile stress on the gene expression profiles of human osteoblasts in vitro.
目的观察人成骨细胞上促甲状腺素受体(TSHR)的表达情况。
Objective To study the expression of extra-thyroidal thyrotropin (TSH) receptors (TSHR) in human osteoblasts (hOB).
目的:应用无桥直接偶联模式合成靶向抗骨肿瘤偶联物甲氨蝶呤-偕二磷酸,并对其进行结构鉴定,了解其体外骨靶向性及对人成骨细胞毒性的影响。
Objective:To synthetize methotrexate-bisphosphonates conjugate by adaptation of directed couple method, and to identify its structure, bone target tropism and the effect of drug on osteoblast.
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