托纳博沙是一种抑制CSD的二乙基溴乙酰胺间隙结合阻滞剂并曾被认为是一种能防止偏头痛的的新化合物。

Tonabersat is a neuronal gap-junction blocker that inhibitsCSD and was once considered a promising new compound to preventmigraine attacks.

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以1，3-二甲基金刚烷为原料，经溴化、 乙腈和硫酸的作用下乙酰胺基化、水解、成盐等反应及改进的后处理方法得到盐酸美金刚，总收率6 7。8%。

Memantine hydrochloride was synthesized from 1,3 dimethyladamantane by bromination, acetamidation with acetonitrile in sulfuric acid and hydrolysis with an overall yield of 67.8%.

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