目的采用主动载药法制备硫酸长春新碱脂质体，考察包封率的影响因素。

OBJECTIVE To prepare vincristine sulfate liposomes by active loading method, and study the influence of different factors on the entrapment efficiency.

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结果被动载药法制备脂质体包封率较低，主动载药制备脂质体包封率为84.38%。

ResultsThe entrapment efficiency with passive loading method was low, while up to 84.38% with active loading method.

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结果被动载药法得到的包封率仅有13.3%，主动载药法的包封率最高可达84 . 6 %。

RESULTS The entrapment efficiency with passive loading was only 13.3%; while up to 84.6% with active loading method.

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