结论MCF-7乳腺癌细胞株中雄激素受体存在自动调节,氟他胺和羟基氟他胺上调雄激素受体的表达。
CONCLUSIONS Androgen can autoregulate the expression of androgen receptor in MCF-7 breast cancer cell line. Flutamide and hydroxyflutamide up regulate the expression of androgen receptor.
结果:40例前列腺癌患者的前列腺癌组织中雄激素受体表达阴性10例,阳性30例,分别为25%和75%,其中强阳性5例,占12.5%。
Results: Androgen receptors of 10 prostate carcinoma patients expressed negative in 40 patients, 30 positive, 25% and 75% respectively, which 5 strongly positive, accounting for 12.5%.
首先,他们用基因手段禁止了细胞受体的活动——细胞受体即那些向其他细胞发送和从其他细胞接受信号的分子们——因为雌激素和雄激素存在于正在发育的老鼠胚胎的肢芽中。
First, they used genetic tools to deactivate cell receptors-molecules that send and receive signals to and from other cells-for testosterone and estrogen in the developing limb buds of mouse embryos.
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