DPC DNA protein cross-linking DNA- 蛋白质交联
DNA-protein cross- linking 蛋白质交联
dna inter-strand cross-linking dna股间交联
The anticancer mechanism of nitrosoureas is very similar to the carcinogenic mechanism, both of them can alkylate DNA bases and form DNA cross-linking further.
亚硝基脲的抗癌与致癌机理是非常接近的,都能够使DNA碱基发生烷化,进一步形成DNA股间交联。
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes;
氧化应激可以导致DNA链断裂、DNA位点突变、DNA双链畸变和原癌基因与肿瘤抑制基因突变等形式的DNA损伤;
Scientists have known that the protein complex known as FANCI-FANCD2 responds to DNA damage and repairs cross-linking, but the details of how the complex works have been unknown.
科学家早已确信存在一种称为FANCI-FANCD2的蛋白复合物,该复合体与DNA损伤及交联修复有并,至于其作用机制尚未可知。
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