Racemic backbones 2-amino-2’-hydroxy-6,6’-dimethyl-l,l’-biphenyl la and 2-amino-2’-hydroxy-4,4’,6,6’-tetramethyl-l,1’-biphenyl 1b were synthesized from o-methylaniline and 2,4-dimethylaniline via nitration, diazotation/iodination, Ullmann coupling, selective reduction, diazotation/hydrolysis and hydrogenation.
从邻甲苯胺及2,4-二甲基苯胺出发,经过硝化,重氮化-碘代,偶联,单还原,重氮化-水解及还原反应合成了消旋体骨架2-氨基-2’-羟基-6,6’-二甲基-1,1’-联苯1a和2-氨基-2’-羟基-4,4’,6,6’-四甲基-1,1’-联苯1b。
参考来源 - 手性联苯骨架的合成及其在不对称催化中的应用·2,447,543篇论文数据,部分数据来源于NoteExpress
应用推荐