Furthermore, results from both clinical trials and animal studies indicate that these complications might progress despite glycemic control, a phenomenon termed metabolic memory.

此外，从临床试验和动物实验研究结果表明，这些并发症的可能，尽管血糖控制方面取得进展，这种现象被称为代谢记忆体。

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But the bigger challenge for many of these compounds is that, despite being in the midst of major phase 3 trials, it is not at all clear that they work.

FORBES: The Difficulties In Predicting Blockbuster Drugs