The most common is that you may feel that it's just not possible to have a satisfying life, and resign yourself to hopelessness and despair.

最常见的是，你可能觉得自己不可能过上满意的生活，因此而屈服于无望和绝望。

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One path leads to despair and utter hopelessness.

一条路通往无望和绝望。

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I vow to comfort myself during times of hopelessness, despair, depression, disillusionment, or any difficulty that arises.

我发誓，在绝望、沮丧、幻灭或任何困难出现的时候，我会安慰自己。

youdao

One path leads to despair and utter hopelessness.

FORBES: The Greek Salad of Pyrrhic Victory,The Battle Of Bunker Hill, And Woody Allen

We the people charge the regime as being guilty of: the privatization of subsoil, the destruction of industry, the starvation of seniors, the homelessness of children, an orgy of ignorance, the degradation of education, beggarly wages and pensions, the limitation of the rights to housing and work, total alienation, fear, despair, and hopelessness.

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Indeed, since April 1, 115, 000 former workers have fled the work force in hopelessness and despair.

FORBES: Magazine Article