Some conclusions were drawn from the binging activity results. 1) Linear peptides exhibit weaker affinity than corresponding cyclic peptides analogues.
初步构效关系表明:1)环肽结构的黑皮素类似物对受体的亲和活性好于相应线肽。
参考来源 - 黑皮素激动类似物的设计、合成和活性评价The interior cavity of the nanotubes is hydrophilic allowing transport of water-soluble small molecules, whereas the exterior can be modified to be hydrophobic by selection of amino acid residues of cyclic peptides.
纳米管内部管道区域呈亲水性,能使水溶性小分子物质通过,而其外壁性质取决于环肽氨基酸残基的性质。
参考来源 - 自组装环肽纳米管介导的药物跨膜转运及其抗肿瘤活性研究·2,447,543篇论文数据，部分数据来源于NoteExpress
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