细胞毒T 细胞相关抗原(CTLA)-4Ig:CTLA-4 (cytotoxicTlymphocyteassociatedantigen)是CD28 同系物,与 CD28 有70%的同源性.CTLA-4 与B,的亲和力约为CD28 的 2o...
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方法:分选AD患者外周血Tregs,通过流式细胞仪检测特征性标志物叉头转录因子(Foxp)-3和表面分子细胞毒性T淋巴细胞相关抗原(CTLA)-4及膜相关转化性生长因子(TGF)-B的表达水平,通过ELISA检测特征性细胞因子TGF-B和白细胞介素(IL)-10分泌水平,并进一步通过Transw...
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表达ICOS,CD28和细胞毒性T淋巴细胞抗原(CTLA)4对肠黏膜固有层单个核细胞(LPMC)与溃疡性结肠炎(UC),克罗恩病(CD),和正常对照组患者用流式细胞仪和免疫组化。
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programmed death (PD)-1, cytotoxic T lymphocyte antigen (CTLA)-4] on activated T cells, activation or induction of regulatory T cells (T regs), and/or production of suppressor cytoki...
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Conclusion CTLA, 4 gene seems to be a new susceptible candidate gene of GD in Cantonese Han population.
结论CTLA - 4基因可能是广东地区汉族人群中GD的易感候选基因。
The enhanced cell surface expression of CTLA-4 is likely responsible for the induction of t cell anergy.
结论CTLA - 4表面表达水平的升高很可能与T细胞无能状态的诱导有关。
Although the mechanism of signaling by CD28and CTLA-4has been well studied, many questions still remain to be answered.
在信号转导机制方面,对CD 28和CTLA - 4研究得比较多,但仍有许多问题未解决。
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