CONCLUSION The CCD-RSM can be applied to optimize the formulation of butoconazole nitrate sustained-release cream and the established model is of satisfactory predictive value.
结论星点设计-效应面法可用于硝酸布康唑缓释乳膏的处方优化，所建模型具有良好的预测能力。
OBJECTIVE To optimize the formulation of tinidazole colon-targeted bioadhesive tablets by the central composite design-response surface methodology (RSM plus CCD).
目的通过星点设计-效应面法优化替硝唑结肠靶向生物黏附片处方。
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