Sickle-cell disease is characterized by a modification in the shape of the red blood cell from a smooth, donut-shape into a crescent or half moon shape.
镰状细胞病的特征是红血球形状发生突变，由平滑的圆圈形状改变为新月形或半月形。
This inherited and sometimes serious anemia is caused by a defective form of hemoglobin that forces red blood cells to assume an abnormal crescent (sickle) shape.
此时红细胞变为镰刀形，并更容易被破坏，从而导致红细胞的慢性缺乏。
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