Objective To explore the effect of thrombin (TB) on the blood brain barrier(BBB) permeability and its possible mechanism.

目的探讨凝血酶（TB）对血脑屏障通透性的影响及其可能机制。

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ConclusionBorneol can enhance the permeability of blood-brain barrier to sodium valproate, but has small influence on blood concentration.

结论冰片可提高血脑屏障对丙戊酸钠的通透性，但对血药浓度影响较小。

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Results (1) Permeability of blood brain barrier was increased in burn and burn with NE stimulating rats, with significantly statistical difference compared with normal control group (P<0.01).

结果（1）烧伤大鼠和NE刺激后的烧伤大鼠血脑屏障通透性增加，与对照组比较差异有统计学意义（P<0.01）。

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