So we all have a big problem.

如此，我们都有一个大问题。

article.yeeyan.org

The point is that people grew unaccustomed to thinking and acting in a responsible and independent way. Herein lies another big problem.

关键是人们变得不再习惯以一种负责任和独立的方式去思考和行动。其中就存在另一个大问题。

《柯林斯英汉双解大词典》

Our hope is that if we feed blueberry juice to a child with this type of tumour, we can intervene and shrink the tumour before it becomes a big problem.

我们的希望是，如果我们给患有这种肿瘤的儿童喂蓝莓汁，我们就能在其成为大问题之前进行干预并缩小肿瘤。

article.yeeyan.org

The other big problem with using human blood for making these blood agar plates is that they're actually not accurate."

VOA: special.2009.08.03

A big problem with this is a lot of Freudian theory is claimed to be validated in the course of psychoanalysis.

这里存在的一个大问题便是,精神分析理论中的很多内容,被认为是能够在精神分析的过程中,得到证实的。

耶鲁公开课 - 心理学导论课程节选

I had an injury as well, so I couldn't stand. That was my big problem.

我受过伤，所以我不能站着。这是我最大的问题。

记忆犹新的作品 - SpeakingMax英语口语达人

Actually, if it continues like this we'll have a problem - a big problem.

NPR: Businesses Hit Hard by Turmoil in Kenya

After all, they needed to solve a big problem and this means learning about the market.

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But it is a start to fix a very big problem in this country.

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