OurGrannyhasbeenlocked awayintheAngryAsylum byFred the agent in white, she's plottingher escape, and she needsYOU to guideherthrough thestreetsonce she's busted out!
Leonardo DiCaprio plays a U.S. Marshal, sent with his partner (Mark Ruffalo) to seek a missing person who has escaped from the Ashecliffe lunatic asylum not that there is much to escape to, since the asylum is on Shutter Island, miles from civilization in Boston Harbor.
In the absurdist plot, inmates escape from an asylum, take over the world and kill everyone who rides a bicycle or whose family has ever had anything to do with bicycles.