Gene targeting technology and its application in research of animal model of human disease were briefed in this paper.

本文就基因打靶技术及其在人类疾病动物模型研究中的应用做一介绍。

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Animal model of human disease plays an important role in medical research, but spontaneous human disease cannot satisfy needs of medical research.

人类疾病动物模型在医学研究中起着非常重要的作用，而自然发生的人类疾病已远远不能满足医学研究的需要。

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Model organisms have proven enormously valuable for studies of human disease mechanisms because regulatory pathways and physiology are so highly conserved throughout the animal kingdom.

因为整个动物王国中的生物，调节通路和生理作用是高度保守的，模型生物在人类糖尿病发病机制的研究中已被证明具有重要的价值。

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