Then, all the quantum chemical descriptors including hardness index, softness index, and electronegativity are made to be correlated with the parameters of anesthetic toxicity of organic pollutants.

同时得到相应的量子化学参数，如：分子最高占有轨道能、分子最低空轨道能、分子偶极矩和分子体积等，并将这些理化参数与有机污染物的麻醉毒性参数相关联。

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But because of the toxicity of the local anesthetic, especially long effect of local anesthetic bupivacaine as the representation with strong toxicity, so application are restrict in clinic.

但由于局麻药的毒性问题，特别是以布比卡因为代表的长效局麻药毒性较强，因此在临床麻醉中的应用受到限制。

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