Studies have shown that protease molecule with two non-active site binding groove (allosteric site), can be used to develop drug resistance against HIV, the new strategy.

但这是一个开始，佩里曼表示，这一研究结果为开发新型的抗艾滋病药物奠定了结构基础。

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When the product accumulates beyond an optimal amount it binds to a site (ALLOSTERIC site) on the enzyme, changing the shape so that it can no longer react with its substrate.

当产物积累超出最佳数量时，它将与酶的一个氨酰基位点(变构位点)结合改变其形状，使其不能长时间与底物发生作用。

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