Many studies in recent years indicated that the activation and translocation of protein kinase C (PKC) of neurons in the dorsal horn of spinal cord was related with hyperalgesia.
但其详细机制并未完全阐明。 近年来研究表明,脊髓后角神经元内蛋白激酶C(PKC)的激活和位移与痛感觉及痛过敏的形成有关。
The mechanisms of its activation and translocation may be associated with the difference of the activation factors or its targets, and the amino acid residues of different phosphorylation site.
其激活和转位机制可能与其不同的活化因子或底物和不同位点的氨基酸残基磷酸化有关。
Conclusion PKC took place translocation activation during cerebral ischemia reperfusion, PKC promoted the expression of FOS and BCL 2. Their complex role influenced the neuronal apoptosis.
结论缺血再灌注期间PKC发生易位激活,PK C促进了FOS和BCL - 2的表达,这几个因素综合作用影响神经细胞凋亡。
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