There was a fatal flaw in the plan.

计划中有一个致命的缺陷。

《牛津词典》

As Permian life-forms declined, they reached a fatal threshold and species succumbed to mass extinction.

随着二叠纪生命形式的衰退，它们达到了一个致命的临界点，物种最终走向了大灭绝。

youdao

It is a fatal leap into nothingness, even though the hero may not be aware that his energy springs from a life deprived of its normal supports.

这是一种致命的进入虚无的跳跃，尽管英雄可能没有意识到，他的力量来自于失去正常支撑的生活。

youdao

sanctions resulting from the launch will deal a fatal blow to six-nation talks aimed at ending the North's nuclear weapons programs.

VOA: standard.2009.03.27

All I want to stress is that my discovery of her was a fatal consequence of that "princedom by the sea" in my tortured past.

我想强调的是，我对她的发现,乃是在扭曲的过去里建筑的那座海边王国的致命后果。

耶鲁公开课 - 1945年后的美国小说课程节选

These are two examples I just gave you of introducing genes that affect the life of a cell, either by making it express a protein that it's not making properly that's important to its life, or by intentionally killing a cell by having it express a fatal gene.

刚才我所举两个例子,都只是影响单一细胞生命过程的,无论是使无法正常表达的重要蛋白,正常表达也好,或是有意地,导入致命的基因杀死细胞也好

耶鲁公开课 - 生物医学工程探索课程节选

But before I ever made it to the trail, I witnessed a fatal road accident.

BBC: Nepal's year-round trekking route

Spending more for flexibility has an attraction, but that could be a fatal attraction.

FORBES: Flexible Corporate Strategy: The Freedom Pipeline Example

On dismounting, he fell and received a fatal blow in the stomach from the horse.

FORBES: Magazine Article