美国可以在不对经济造成重大损害的情况下，帮助遏制气候变化带来的最坏影响，并确保子孙后代的生活方式得以延续。

The U.S. can, without major damage to the economy, help halt the worst effects of climate change and ensure the survival of its way of life for future generations.

youdao

我的想法是，将这一点与仔细的监督、强大的组织文化结合起来，确保你使用的目标具有建设性，不会对组织造成重大损害。

My idea would be to combine that with careful oversight, a strong organizational culture, and make sure the goals that you use are going to be constructive and not significantly harm the organization.

youdao

乙方违反劳动合同，对甲方造成重大损害的。

Party B violates employment contract, which causes great damage for Party a.

youdao