皮肤保持一定的水分、动态平衡和正常皮肤外观需要完整的表皮屏障（epidermal barrier），否则会引起经表皮失水率（TEWL）的增加，导致肌肤干燥症，其特征：干燥、脱屑、粗糙、细裂缝以及瘙痒。
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当表皮屏障功能障碍，真皮和表皮内水分会大量丢失，发生皮肤干燥、鳞屑、瘙痒。
When the epidermal barrier is blocked, water in dermis and epidermis will lose, which results in dry skin and skin scales.
目的：建立具有正常皮肤样水渗透屏障功能的人拟表皮模型。
Objective:To establish an in vitro human pseudo-epidermis model with epidermis-like water permeation barrier function.
目的探讨表皮渗透屏障对化妆品功能评价的影响。
Objective To study the effects of light damages of epidermal permeability barrier on cosmetics function evaluation.
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