经体外蛋白质—蛋白质之间的相互作用和蛋白质印迹杂交方法进一步验证了PBP1和BNP23的相互作用；
In vitro the interaction between BNP23 and PBP1 was ascertained by means of the protein-protein interaction and western blotting.
例如，通过物理上蛋白质-蛋白质相互作用的大规模识别，产生了全面的蛋白质相互作用图谱。
For example, through the large-scale identification of physical protein-protein interactions, comprehensive protein interaction maps are being generated.
但是蛋白质复合物相互作用界面的一些特点和性质，如相互作用界面较大、结合界面较为平坦等，使蛋白质-蛋白质相互作用及其抑制剂研究充满了挑战。
However, it is full of challenge to design such inhibitors because of the unique properties of the protein-protein interfaces. For example, the interface is usually big and rather flat.
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