近二十年来，通过研究传统的单细胞耐药模型使我们对耐药机制有了一定的认识。

In the past twenty years, primary understanding of the mechanisms associated with drug resistance has been ascertained through investigating unicellular drug-resistant models.

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此外，美国国际开发署还建立了一个多耐药模型项目(这个项目和肺结核、艾滋病服务是一体的)，在地区和当地宣传扩展肺结核专业知识。

Additionally, USAID created a model multi-drug resistant program, integrated TB and HIV services, and expanded TB expertise at zonal and local levels.

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目的通过体外药效学模型探讨预测抑制细菌耐药突变的PK/PD参数折点。

Objective To determine the PK/PD parameters which is more dependent on the inhibition of resistant mutants using vitro pharmacodynamic model.

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